Neurofilament Light Chain Measurement with Electrochemiluminescence Method (NFL-ECL) in Cerebrospinal Fluid as Promising Diagnostic Method of Amyotrophic Lateral Sclerosis: A Literature Review
Leonardo Wiranata Soesilopranoto, Yesyurun Sekundus Torrys, Randy Martianus, Tjokorda Istri Pramitasuri, Ida Ayu Sri Wijayanti, I Putu Eka Widyadharma.
ALS is one of the neurodegenerative diseases that have high morbidity and mortality. Beside difficulties to manage, it also has a limited diagnostic method to detect ALS in early onset. Neurofilament Light Chain (NFL) is a component of cerebrospinal fluid (CSF) which regulate axon diameter calibration and conduction speed in action potential of neurons. In this review, several literatures were evaluated and selected. The NFL measurement with ECL method has high sensitivity and specificity, that makes this method reliable to use in the diagnosis of ALS.
Key words: Neurofilament Light Chain, Electrochemiluminescence, Amyotrophic lateral sclerosis, Diagnostic