Abstract

Coronary artery disease (CAD) is strongly associated with increased oxidative stress, and 8-hydroxydeoxyguanosine (8-OHdG) is a key biomarker reflecting oxidative deoxyribonucleic acid (DNA) damage; however, its clinical relevance in angiographically confirmed CAD patients remains insufficiently defined. This study aims to investigate 8-OHdG levels, which indicate oxidative DNA damage, in patients with CAD diagnosed by coronary angiography and to evaluate the relationship between the presence of CAD and oxidative DNA damage. This prospective study included a total of 100 individuals: 50 individuals diagnosed with CAD based on coronary angiography results (Group 1) and 50 healthy individuals with normal coronary arteries (Group 2). Plasma 8-OHdG levels were measured from venous blood samples taken from both groups using the ELISA method. The groups were similar in terms of age, gender, height, weight, body surface area, and ejection fraction percentage (p>0.05). The 8-OHdG level was significantly higher in the CAD group (0.42±0.06 ng/mL), and this increase was statistically significant when compared to the control group (0.25±0.05 ng/mL; p < 0.001). This finding indicates that oxidative DNA damage is markedly increased in CAD. Patients in the CAD group were classified angiographically according to vessel involvement, with multivessel disease being predominantly observed. The significantly elevated levels of 8-OHdG in coronary artery disease patients support the notion that oxidative DNA damage plays an important role in CAD pathogenesis. 8-OHdG may be a potential molecular biomarker for CAD. Further investigation of this relationship in larger, multicentre studies is recommended.

Key words: Coronary artery disease, oxidative stress, 8-OHdG, oxidative DNA damage, biomarker, coronary angiography