Background:Laryngeal Mask Airway (LMA) keeps a patients airway open during anaesthesia. When propofol is used along with either fentanyl or dexmedetomidine, it provides stable cardiorespiratory condition, diminished airway reflexes and smooth insertion of LMA.
Aim: Aim of this study is to compare the hemodynamic and respiratory parameters and patients response to LMA insertion between dexmedetomidine-propofol and fentanyl-propofol combinations as a primary outcome. Secondary outcome is to observe any side effect in intraoperative and postoperative period associated with the study drugs.
Methodology: Prospective, double blind, randomized clinical study in 140 healthy patients of both sex, having ASA grade I and II was carried out. Patients were demographically similar. Patients were randomized to receive either intravenous (i.v.) dexmedetomidine(1μg/kg)propofol(2mg/kg) injections- Group D (n = 70) or i.v. fentanyl(1μg/kg)-Propofol(2mg/kg) injections- Group F (n = 70) for LMA insertion. Parameters like heart rate(HR), respiratory rate (RR), systolic blood pressure(SBP), diastolic blood pressure(DBP),oxygen saturation(SpO2%) were recorded baseline, during LMA insertion, 1, 3, 5, 10, 15, 30 minutes (min.) after LMA insertion.Patient's response to LMA insertion such as jaw mobility, coughing/movement were noted. Other side effects were observed.
Results: Significant decrease in HR, SBP, DBP in patients of group Dthroughout the study procedure. In group-F there was rise in the above parameters noted 1st and 3rd minute after LMA insertion. The difference was statistically highly significant between the two groups throughout the procedure.(p
Key words: Injection (inj.) propofol, inj. dexmedetomidine, inj. fentanyl, laryngeal mask airway, LMA insertion
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