Abstract

Aim: This study aimed to evaluate the relationship between anti-thyroid peroxidase antibody (anti-TPO) levels and hematological markers of systemic inflammation — including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and systemic immune-inflammation index (SII) in treatment-naïve patients with Hashimoto’s thyroiditis (HT).
Materials and Methods: This retrospective, cross-sectional study included 416 newly diagnosed, treatment-naïve HT patients. Participants were categorized into low (n=208) and high (n=208) anti-TPO groups based on the median anti-TPO value (208 IU/mL). Thyroid function tests and complete blood count parameters were analyzed, and NLR, PLR, MLR, and SII were calculated. Spearman’s correlation and multivariable linear regression analyses were performed.
Results: The high anti-TPO group had significantly higher TSH [5.87 (3.60–10.07) vs. 4.14 (2.62–6.60) µIU/mL; p

Key words: Hashimoto’s thyroiditis, anti-TPO, systemic inflammation