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Original Article

PAFMJ. 2018; 68(2): 369-373


NEURO-PSYCHIATRIC MANIFESTATIONS OF HASHIMOTO THYROIDITIS; A CASE SERIES

Jahanzeb Liaqat, Waseem Raja, Waseem Wali, Muhamad Umar Javed.

Abstract
Hashimoto Encephalopathy (HE) or Steroid-Responsive Encephalopathy associated with Autoimmune
Thyroiditis (SREAT) is a rare autoimmune disease characterized by encephalopathy and elevated anti-thyroid
antibodies in the absence of a central nervous system (CNS) infection, tumour or stroke. Clinical presentation of
HE includes amnestic syndrome, seizures including status epilepticus, ataxia, myoclonus and psychiatric
manifestations like depression, mania, psychosis and hallucinations. A good clinical response can be achieved
with corticosteroid therapy so early diagnosis and treatment is very beneficial for patients. Here we report four
patients with Hashimoto encephalopathy who had neuro-psychiatric manifestations of the disease and had
detectable thyroid specific antibodies in the serum (thyroperoxidase antibody formerly known as antimicrosomal
antibody). All these patients showed an objectively significant response to methylprednisolone
treatment.

Key words: Autoimmune disease, Encephalitis, Hashimoto thyroiditis



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