Objective: Antipsychotics is a group of psychotropic drugs used as the mainstay treatment for schizophrenia. In Indonesia, studies on the pattern of drug use are still limited, particularly about the rational use of antipsychotics for schizophrenic patients. This study was aimed to discuss the treatment patterns of antipsychotics and clinical features of inpatients with schizophrenia.
Irrational drug use will affect the effectiveness of the drug, as well as increase the incidence of side effects and drug interactions.
Methods: This retrospective study was conducted at the psychiatric ward of a tertiary hospital in Jakarta, Indonesia. The medical records of the inpatients in a year period (July 2014 June 2015) were recorded. during the hospitalization. The evaluation of rational use of antipssychoyics was assessed using clinical pathway in the hospital and some international guidelines. The data were documented by using specific forms for the sake of this study.
Results: In this study, of the 113 analyzed patients, the most commonly type of schizophrenia wasis paranoid, while the most commonly prescribed medication antipsychotics: were risperidone (63.7%), haloperidol (20.4%) and quetiapine (19.5%). Surprisingly, we found that 73.4% patient met one or more criteria of inappropriateness treatment and majority caused of inappropriateness were inappropriate indication (41.6%).
Conclusion: In this study, we find out found that schizophrenia inpatients were administered to a large number of inappropriate treatments. Knowledge regarding medications, especially the implementation of clinical pharmacology contributions to the psychiatrists might improve the prescriptions pattern.
Key words: Antipsychotic, rationality, schizophrenia, teaching hospital