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Kolaviron modulates intestinal motility and secretion in experimentally altered gut functions of Wistar rats

Olugbenga Adeola Odukanmi, Adeola Temitope Salami, Oyenike Lola Morakinyo, Oluwole Emmanuel Yelotan, Samuel Babafemi Olaleye.


Abstract

Aim: The effect of kolaviron, a complex of Garcinia kola (GK) naturally rich in bioflavonoid, was investigated on intestinal motility and secretion in altered gut functions of rats.
Methods: Four experiments were carried out using Male Wistar rats, (189.1 ± 3.5 g). The first was for intestinal transit with charcoal meal, and rats were grouped into 4 (n=5/group in all experiment): Control (DMSO); Atropine (5 mg/kg), 100 mg/kg (KV100) and 200 mg/kg (KV200) kolaviron groups respectively. Experiments 2 and 3 were to assess diarrhea and enteropooling respectively; the animals were grouped into 6: negative control (DMSO), positive control (castor oil), Atropine (5 mg/kg), Loperamide (3 mg/kg), KV100 and KV200 respectively. Experiment 4 was to determine colonic motility and it consist of 5 groups, negative control (DMSO), and positive control (Serotonin, 5 mg/kg, ip), Atropine (5 mg/kg), KV100 and KV200 in turn.
Results: Kolaviron significantly decrease intestinal transit in similar way to atropine group, KV200 (27.3%), KV100 (25.7%) compared with control. The onset of diarrhea was prolonged significantly while episodes of loose stool and purging index decreased significantly with loperamide (111.0 min, 0.4 ± 0.2, 0.1) and KV200 (128.8 min, 2.6 ± 0.7, 2.0) compared with control (52.6 min, 6.6 ± 1.0, 15.6), respectively. Kolaviron significantly reduced luminal fluid in KV100 (1.04 ± 0.17 mL) and KV200 (0.62 ± 0.21 mL) compared with control (1.70 ± 0.18 mL). Colonic motility was delayed in KV200 (182 ±18.7 sec) compared with control (139 ± 8.72 sec).
Conclusion: Kolaviron exhibits potent anti-motility and -secretory activities on destabilized gut homeostasis and could be the major compound of Garcinia kola responsible for previously reported antidiarrheal effect.

Key words: Intestinal motility, Intestinal secretion, Kolaviron, Garcinia kola, Diarrhea






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