RP-HPLC method for Simultaneous estimation of bulk and tablet dosage forms. Separation of Alogliptin and
Metformin hydrochloride was achieved ODS C18 (4.6×250mm,5µm,Hypersil) or equivalent in an isocratic
mode using Acetonitrile :water : Methanol (70:20:10) v/v at a flow rate of 0.8ml/min and elute was observed at
278nm, with a retention time of 1.336 and 2.186 minutes for Metformin and Alogliptin respectively. The
method was linear in the drug concentration range of 1µg/ml to5µg/ml for Metformin and 1µg/ml to 5µg/ml for
Alogliptin. The values of the correlation coefficient were 0.986 for Metformin hydrochloride and 0.967 for
Alogliptin respectively. The LOD and LOQ for Metformin hydrochloride and Alogliptin were 0.174 and 0.527
and 0.120 and 0.3099 respectively. The Metformin and Alogliptin recovery percentage is 99 and 100
respectively. The specificity of the method observed the non interference of impurities in sample. As per ICH
guidelines the method is verified with parameters such as Linearity, Accuracy, Precession, Specificity and
Alogliptin and Metformin hydrochloride, Antidiabetic drugs, RP-HPLCmethod
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