Background: Modified radical mastoidectomy is a microscopic ENT procedure which when performed under general anesthesia (GA) required nitroglycerin for control of intraoperative bleeding at the surgical site. When dexmedetomidine used as an adjuvant to anesthetic drugs, nitroglycerin is rarely used.
Objective: The aim of this study is to evaluate the efficacy of dexmedetomidine on the reduction of intraoperative bleeding in modified radical mastoidectomy under GA.
Materials and Methods: This study was conducted on 100 adult ASA Grade I/II patients of either sex, scheduled for modified radical mastoidectomy under GA. Grading of bleeding at the surgical site, a number of patients required nitroglycerin for control of bleeding were recorded.
Results: No patient in Group D required nitroglycerin for reduction of bleeding, but 40 patients in Group C required nitroglycerin for reduction of bleeding. The overall incidence of significant bleeding which required frequent suctioning in control group was 40 (80%) compared with 0 (0%) in the dexmedetomidine group.
Conclusion: Infusion of dexmedetomidine in perioperative period significantly reduced the requirement of nitroglycerin for controlled hypotension.
Key words: α2-Adrenoceptor, Dexmedetomidine, Heart Rate, Mean Arterial Blood Pressure
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