Introduction: Propolis is an important characteristic because it contains bioactive substances such as total phenolics, total flavones, flavonols, total flavanones and dihydroflavonols. Cancer is a large group of disorders characterized by uncontrolled cellular proliferation. It is one of the most devastating diseases all over the world. Recently, there is an increased interest in the clinical use of natural products as a safe, efficient, and economic therapeutic alternative. Honey bee products therapy, apitherapy, was used to control various diseases including cancer. Objectives: The primary objective of this study was to screen potential cytotoxic effects of propolis sample against different cancer types. Materials and Methods: Samples of propolis were collected from Bulgaria, Libya and Egypt and tested by MTT cell-based assay against liver (HEP-G2), breast (MCF-7) and colorectal (Caco-2) cancer cell lines. Results: The results showed that Libyan propolis proved to be most active among all tested propolis samples HEP-G2 (84.99%), MCF-7 (83.57%) and Caco-2 (79.63%). Conclusion: The results showed that propolis it is interesting agents that have valuable activities against HEP-G2, Caco-2 and MCF-7 with propolis being an effective agent that might be incorporated in cancer remedy regimens after further studies.
Apitherapy, HEP-G2, Caco-2, MCF-7, Propolis