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Original Research

Clinical and biochemical profile of non-diabetic chronic kidney disease patients: A prospective study

Deepankar Lahariya, Anvesh Singh Parmar.


Background: Chronic kidney disease (CKD) is one of the raising health issues globally. Patients who are in the last stage (Stage 5) of CKD can only be treated using renal replacement therapy mainly hemodialysis. Patients undergoing hemodialysis often face disturbed routine life and also report dissatisfaction following treatment.

Objectives: The objectives of this study were to study the clinical and biochemical profile of non-diabetic CKD patients.

Materials and Methods: A total of 100 CKD patients were studied in the Department of Medicine, GR Medical College and JA Group of Hospitals, Gwalior, from February 2014 to November 2015. After detailed history, complete blood count, blood urea, serum creatinine, serum albumin, total protein, albumin-to-creatinine ratio, and albumin excretion ratio were estimated in all the patients.

Results: Most of the patients in cases (23%) belong to the age group of 51–60 years with male predominance (56%). The most common symptom was swelling of legs (70%) followed by oliguria (62%), whereas the most common sign was pallor (76%) followed by edema (70%). Most of the patients (61%) were hypertensive. Maximum patients were from glomerular filtration rate G5 category (69%). Most of the patients were of A3 albuminuria category (76%). Mean hemoglobin, blood urea, serum creatinine, total protein, and serum albumin in non-diabetic CKD patients were 8.06 ± 2.34, 156 ± 92.32, 7.56 ± 5.22, 6.11 ± 0.93, and 3.11 ± 0.65, respectively.

Conclusion: CKD was common in male patients who were in the 6th decade of life. Swelling of legs, oliguria, pallor, and edema were the common signs and symptoms in non-diabetic CKD patients. Awareness regarding the factors responsible for CKD is important to lower the incidence and even delay the progression to end-stage renal disease.

Key words: Serum Creatinine; Swelling of Legs; Hypertension; Non-diabetic Chronic Kidney Disease

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