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Evaluation of the Antioxidant Property of NO Donors against Vascular Damage Induced by Cyclosporine along with High Fat Diet

Rekha Cheruvara, Bharani Kalakumar, Shwetha Reddy RV, Sarin K Kunnath, Anitha Nalla, Gopala Reddy.


From this study it was concluded that the degree of vascular damage induced by Cyclosporin (CsA) with high fat diet is significantly attenuated by the administration of nitric oxide donors L-Arginine and L-Citrulline. The protective effect of the amino acid supplements in vascular system could be well explained with the vasodilatory, antioxidant and regulatory properties of NO. The effects of L-Arginine were comparable to L-Citrulline, while the combination of L-Arginine and L-Citrulline was found superior in this study. Hence, with this present study, it could be demonstrated that, at least in mice, the ability of nitric oxide boosting substances, including L-Arg and L-Cit to ameliorate the biochemical changes and reverse the progression of vascular disorders induced by cyclosporine along with HFD.

Key words: Cyclosporine, L-arginine, L-citrulline, Nitric Oxide, Antioxidant Profile

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