Background: High-fat-diets could induce obesity, also leading to increase inflammation and insulin resistance
Purpose: The aim of this study was to examine weight gain, insulin sensitivity, and serum inflammatory biomarkers after feeding female rats different high-fat-diets for 6 weeks.
Materials and Methods: Eight weeks Sprague-Dawley female rats were randomly divided into three main dietary groups: rats were fed the high saturated fat diet group (HSFD; n=6), rats were fed the high monounsaturated fat diet group (HMUSFD; n=6) and rats were fed normal fat diet group (NFD) (n=6), for 6 weeks. Blood samples were collected; serum glucose, insulin, C- reactive protein (CRP), interleukin-6 (IL-6) and leptin were analyzed.
Results: Findings of this study demonstrated that no significant elevation in weight gain, FBG, insulin and HOMA-IR in rats that were fed HFDs as compared to rats that were fed NFD. Also, the inflammatory biomarkers that mentioned
(IL-6, leptin and CRP) did not significantly affected by feeding rats HFDs as compared to rats that were fed NFD.
Conclusion: High-fat-diets did not induce weight gain, insulin resistance and inflammation on female rats after short period of time.
Key words: high-fat-diet; insulin resistance; weight gain; leptin; IL-6; CRP
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