Abstract

Diabetes mellitus remains a significant global health challenge, often leading to weight loss, hyperglycemia, dyslipidemia, and oxidative stress. Irvingia gabonensis (commonly known as Ogbona) is a medicinal plant with ethnobotanical relevance in the management of metabolic disorders. This study aimed to evaluate the antidiabetic and antihyperlipidemic effects of different parts of Ogbona seed—whole, peel, and kernel administered at varying doses in alloxan-induced diabetic rats. Diabetes was induced using alloxan monohydrate (150 mg/kg, i.p.) in albino rats. Experimental groups (n=6) received oral treatments of whole seed (WO), peel (OP), and seed kernel (OS) at doses of 100, 200, and 300 mg/kg body weight for 21 days. Metformin (500 mg/kg) served as the standard drug. Parameters assessed included body weight, fasting blood glucose, total haemoglobin (Hb), glycated haemoglobin (HbA1c), lipid profile (TC, TG, HDL, LDL, VLDL), and atherogenic index (AIX). Alloxan-induced diabetic rats showed significant weight loss, hyperglycemia (14.59 ± 1.21 mmol/L), decreased Hb (8.49 ± 0.47 g/dL), increased HbA1c (8.06 ± 0.68%), and elevated lipid profile. Treatment with Ogbona significantly (p

Key words: Irvingia gabonensis, diabetes, lipid profile, blood glucose, haemoglobin, atherogenic index