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TThyroid dysfunction in chronically transfused adults with β-thalassemia major

Handan Haydaroglu Sahin, Ilkay Dogan.

Abstract
Aim: This study aims to determine the prevalence and severity of thyroid dysfunction in adult β-thalassemia major (BTM) patients and to investigate its relationship with the frequency of transfusions, serum ferritin levels, and adequacy of oral chelation therapy.
Material and Methods: This study included 62 adult patients diagnosed BTM and had been receiving regular blood transfusions for at least 1 year. Iron load was defined as the serum ferritin level. Thyroid dysfunction was categorized as primary hypothyroidism (thyroid-stimulating hormone (TSH)>5.6 mU/L and serum-free thyroxine (FT4)5.6 mU/L) or secondary hypothyroidism (FT4

Key words: β-Thalassemia Major; Serum Ferritin Level; Hypothyroidism.


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