This study aimed to evaluate the effect of green tea extract (GTE) and vitamin C as antioxidants on the biochemical oxidative stress parameters and histopathological changes induced by fenitrothion pesticide in liver and kidney of albino rats. Twenty-four rats were divided into four groups; group one (control), group two received 10 mg/kg b.wt. of FNT orally, group three received FNT daily plus green tea extract at a concentration of 3% w/v and group four received FNT daily plus vitamin C at a concentration of 2 g ascorbic acid/l water. The experiment was conducted for six weeks. Blood samples were taken for biochemical parameters, but the histopathological studies were carried out on liver and kidney tissues at the end of the experiment. Damage in the tissue samples was observed and confirmed with elevation of oxidative stress marker (MDA). Exposure of rats to fenitrothion induced significant increase of MDA and decrease in the values of SOD, GSH, CAT, TAC compared to control one in both serum and tissues samples. However, administration of green tea and vitamin C to FNT treated group decreased in the values of MDA and improved the values of SOD,GSH and CAT toward the control values in both serum and tissues but could not normalize it. Total antioxidant capacity (TAC) level showed a significant increase with FNT plus vitamin C and the FNT plus GTE treated groups compared to the FNT group. Green tea and vitamin C, probably due to their strong antioxidant properties could improve and partially counteracts the toxic effect of FNT on oxidative stress parameters and repair the destructive effects of its damage in rat's liver and kidney tissues especially with GTE treated groups.
Key words: Fenitrothion, toxicity, green tea, vitamin C, histopathology, antioxidant enzymes, rats.
Identification of key genes involved in axon regeneration and Wallerian degeneration by weighted gene co-expression network analysis.
Lu Y, Shan Q, Ling M, Ni XA, Mao SS, Yu B, Cao QQ
Neural regeneration research. 2022; 17(4): 911-919
Computational Modeling of Glycan Processing in the Golgi for Investigating Changes in the Arrangements of Biosynthetic Enzymes.
West B, Wood AJ, Ungar D
Methods in molecular biology (Clifton, N.J.). 2022; 2370(): 209-222
Functional Characterization of Target Genes Associated with Insecticide Resistance of the Green Peach Aphid, Myzus persicae.
Fosu-Nyarko J, Iqbal S, Brigg F, Jones MGK
Methods in molecular biology (Clifton, N.J.). 2022; 2360(): 187-208
Genome-Wide Identification and Validation of Target Genes Associated with Insecticide Treatment of the Green Peach Aphid, Myzus persicae.
Iqbal S, Fosu-Nyarko J, Brigg F, Jones MGK
Methods in molecular biology (Clifton, N.J.). 2022; 2360(): 119-138
Rapid Screening of Myzus persicae (Green Peach Aphid) RNAi Targets Using Tobacco Rattle Virus.
Feng H, Jander G
Methods in molecular biology (Clifton, N.J.). 2022; 2360(): 105-117