Abstract

Over the decades, plant-derived phytochemicals have attracted attention as potential therapeutics for wound healing. Moringa oleifera Lam. (M. oleifera) has been traditionally used as herbal remedy in wound healing. To our knowledge, there is a lack of a comprehensive synthesis of evidence on M. oleifera’s wound healing properties. This review aimed to identify literatures that evaluated the pharmaceutical applications of M. oleifera plant in wound healing through in vivo and in vitro studies. Following the PRISMA-ScR guideline, a comprehensive scoping review was conducted on four major electronic databases (ScienceDirect, PubMed, Academic Search Complete, and Semantic Scholar) from 2014 to June 2025 for in vivo or in vitro studies, that evaluated the effects of M. oleifera on wounds. The search on four databases produced 47 studies. Findings revealed that M. oleifera exhibited wound healing activity, through cell proliferation and wound contraction, particularly the leaves of M. oleifera extract also demonstrated increased tensile strength and proliferation rate of wound, and exhibited anti-inflammatory, antioxidant, anti-diabetic, and anti-bacterial properties. Further research should investigate the bioactive compounds in M. oleifera, and the molecular healing mechanisms of M. oleifera.

Key words: Moringa oleifera, wound healing, in vivo, in vitro, bioactive compounds