Aim: Obesity is a chronic health problem characterized by excess fat accumulation. This study aimed to assess the levels of endoplasmic reticulum stress–associated Tribbles homolog 3 (TRB3), oxidative stress–associated Sestrin 2 (SESN2), paraoxonase-1 (PON1) activity, and the atherogenic index of plasma (AIP) in obese, overweight, and normal-weight individuals, and to investigate their relationship with obesity.
Materials and Methods: The study enrolled 172 individuals, who were classified into normal-weight, overweight, and obese groups based on their BMI. TRB3 and SESN2 levels were measured using ELISA, and PON1 activity was assessed using spectrophotometric methods.
Results: Obese participants exhibited reduced PON1 activity and SESN2 levels compared with normal-weight individuals (p
Key words: Sestrin 2, tribbles homolog 3, paraoxonase-1, obesity, atherogenic index of plasma
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