Abstract

Background:
R Feline infectious peritonitis (FIP) is a viral infection in cats that develops when a coronavirus mutates and causes an immune reaction throughout. The disease is usually fatal and requires extreme care to save the animal.

Aim:
This study examined the albumin-to-globulin (A/G) ratio as an important marker for monitoring the therapy effect. Simultaneously, the hematological and biochemical profiles of cats suffering from FIP were explored following intravenous treatment with remdesivir.

Methods:
Intravenous remdesivir was administered to 45 confirmed cases of FIP pets for 60 days. The cats were aged 3 months to 2 years because this is the most susceptible age in feline animals. Clinical data were collected at both the start and end of the 60-day period to examine the A/G ratio and monitor the hematological and biochemical profiles.

Results:
A significant alteration in the albumin concentration, A/G ratio, and lymphocyte counts was found after remdesivir administration for 60 days. The creatinine-to-Blood Urea Nitrogen ratio was also altered, indicating an improvement in renal metabolism or protein turnover. No significant changes were found in protein and globulin levels, Red Blood Cell indices, platelet counts, electrolytes, and minerals. We also did not find evidence of hepatic injury. Liver enzymes, including Alanine Aminotransferase, Aspartate Aminotransferase, and Gamma-Glutamyl Transferase, the ALT/AST ratio, and total bilirubin did not change, indicating no evidence of remdesivir-induced hepatic injury.

Conclusion:
The A/G ratio is useful to indicate recovery in FIP-affected cats.

Key words: Albumin; Globulin; A/G ratio; FIP; Coronavirus.