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J App Pharm Sci. 2018; 8(12): 104-111

Hepato-toxic Risk of Gum Arabic during Adenine-induced Renal Toxicity Prevention

Entsar A Saad, Hussam A El-Gayar, Reda S EL-Demerdash, Kholoud H Radwan.


We aimed to highlight the potential effects of gum Arabic (GA) administration to rats with adenine (AD)-induced CRF through investigating kidney and liver changes on biochemical and histological levels. Creatinine, urea, uric acid, blood urea nitrogen (BUN), aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin, bilirubin and cholesterol levels were estimated. Renal and hepatic malondialdehyde, superoxide dismutase and catalase were estimated also. Kidney and liver tissues were histo-pathologically examined. GA supplement efficiency in preventing AD-induced renal toxicity is clearly revealed. It is evident from histo-pathological examination and reduced urea, BUN, and creatinine levels. Also, it is proven that GA supplementation produces harmful effects on liver as it elevates ALT and AST levels. Thus, we conclude that GA supplement utilization to treat CKD patients must be done under medical supervision and liver function tests should be monitored during treatment course. It would be more benefit for such patients to use a hepato-protective supplement in addition to GA supplement for better outcomes.

Key words: Antioxidants; Gum Arabic; Liver damage; Nephro-protective; Renal failure.

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