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Hypolipidemic effects of Lysinibacillus sphaericus fermented tomato and carrot juices in high fat diet fed Albino Wistar rats

Naga Sivudu Seelam, Umamahesh Katike, Peddanna Kotha, Harika Akula, Vijaya Sarathi Reddy Obulam.

Abstract
The present study was to evaluate the effect of probioticated tomato (PTJ), probioticated carrot juice (PCJ) and their mixed juices (PCT) containing Lysinibacillus sphaericus on high fat diet (HFD) fed Albino Wister rats. Eight groups consisting of 6 rats each was designed in the experiments and orally administrated the above probioticated juices (at 1 to 2 mL per rat) to HFD fed rats for 28 days. This included a group maintained on normal (NCD) and control diet (HFD) and an experimental control group maintained by Lovastatin (at 5 mg/kg body weight). After feeding the rats, the lipid profile of the blood serum was studied in all the groups. HFD fed rats showed elevated lipid profile levels as compared to NCD fed rats. Probioticated juices reversed the elevated lipid profile levels to near normal in HFD fed rats. This hypolipidemic effect was more significant in PCJ fed (2 mL/rat) groups than the other groups. On treatment with the probioticated tomato (PTJ), carrot (PCJ) and their mixed juices (PCT), the body weights of the treated groups were significantly lowered in HFD fed rats as compared to control group.

Key words: Probiotication, tomato, Carrot, Lysinibacillus sphaericus, High fat diet, Albino Wistar rats, hypolipidemic activity


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