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Assessment of biomarkers in acrylamide-induced neurotoxicity and brain histopathology in rat

Sreenivasulu Dasari, Muni Swamy Ganjayi, Sailaja Gonuguntla, Keerthi Ramineedu, Prabhakar Yellanur Konda, Balaji Meriga.


The effects of acrylamide (ACR), a synthetic neurotoxic chemical compound on non-enzymatic and enzymatic stress markers and brain histopathology were studied in wistar rats. ACR (50 mg/300 ml) was ingested through drinking water on alternative days and brain tissues were collected on 13th and 27th days post ingestion for analysis. Results revealed that ACR causes significant increase in non-enzymatic stress markers like lipid peroxidation (p

Key words: acrylamide; stress markers; brain degeneration

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