Evaluation of Serum Lipid Parameters in Acromegaly Patients
In Acromegaly, the incidence of cardiovascular disease is higher than that of healthy population because of the association of secondary cardiovascular disease risk factors such as hypertension, glucose intolerance, dyslipidemia, and insulin resistance. This study aimed to evaluate the newly diagnosis of acromegaly patients of lipid profile and relationship between investigated Growth Hormone (GH), Insulin-like Growth Factor-1 (IGF-1).
The study included 57 acromegaly patients and 31 people as a control group without any systemic disease. Blood samples were taken for hormones, lipid levels and fasting blood glucose after a-12 hours night hunger.
In this study the mean of LDL-C level in the acromegaly group and control group were respectively 140.2± 61.3 mg/dl and 115.6± 30.4 mg/ dl, (p=0.029), triglyceride level 137.6 ± 84.0 mg/dl and 102.9 ± 43.0 mg/ dl, (p=0.027) and HDL-C level 41.5± 10.5 mg/ dl and 50.5±10.6 mg/ dl, (p=0.001).
There was a significant positive correlation between GH levels of LDL (r=0.375, p=0.002), TG (r=0.302, p=0.01), IGF-1(r=0.634, p=0.0001) and HOMA-IR (r=0.699, p=0.0001), IGF-1 and LDL levels (r=0.295, p=0.01) and TG (r=0.476, p=0.0001 ). There was a negative correlation between HDL and GH (r= -0.399, p =0.001) and HDL with IGF-1 (r=-0.310, p=0.01).
Acromegaly is a disorder characterized by an excess of growth hormone in patients with a diagnosis of growth hormone appears to adversely affect the lipid profile compared to healthy people. Obtaining the remission on the Acromegaly by the controlling onto GH and IGF-1 levels, disappearing of these risc factors may be thought. Further studies are needed.
Acromegaly, Dyslipidemias, atherosclerosis
Article Language: Turkish English