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Original Article

PAFMJ. 2018; 68(1): 149-153


ASSOCIATION OF PLASMA LEPTIN WITH CORONARY ARTERY CALCIUM (CAC) IN ADULTS

Sheharbano Imran, Zainab Hussain, Lena Jafri, Hafsa Majid, Zaffar Sajjad, Aysha Habib Khan.

Abstract
Objective: To determine the correlation between leptin and CAC in scores subjects without cardiovascular
disease (CVD) risk.
Study Design: Cross sectional study.
Place and Duration of Study: Aga Khan University Hospital, from Mar 2014 to Jun 2015.
Material and Methods: Total 128 subjects were included. The study was approved by ethical review committee.
After informed consent a predesigned questionnaire was documented. Subjects without known cardiac disease
history, coming for non-contrast CT scan for abdominal indications were included. Leptin levels were measured
by Enzyme immunoassay. CAC scores were assessed on a 64 slice non-contrast CT scan. Data analyzed by SPSS
version 20.
Results: Total 128 subjects were included with mean age 42.82 13.1 years and 78.1% (n=100) were males. Mean
BMI and waist circumference was 27.1 5.4 kg/m2 and 94.8 9.0cm respectively. High median leptin levels were
seen in 11.7% (n=15) of study subjects. Leptin levels were also significantly higher in female compared to male
[12.5ng/ml (0.3-60.9) vs. 2.5ng/ml (0.1-50); p-value=0.001]. High CAC score was present in 15% (n=19) of study
subjects.
Statistically significant correlation of leptin was found with waist circumference, (r 0.50; p=0.001), positive
correlation with BMI (r 0.51, p

Key words: BMI, Leptin, Obesity, Waist circumference.



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