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Original Article

PAFMJ. 2018; 68(1): 119-124


IS GUILLAIN-BARRÉ SYNDROME DIFFERENT IN PAKISTAN?

Waseem Iqbal, Tahir Mukhtar Sayed, Wasim Wali, Nadeem Ahmed, Aamir Waheed Butt, Zaheer Ahmad Gill.

Abstract
Objective: To assess clinical presentations and subtypes of Guillain-Barré Syndrome (GBS) in Pakistan.
Study Design: Retrospective study.
Place and Duration of Study: CMH Lahore, Abbotabad, Quetta & Armed Forces Institute of Rehabilitation
Medicine form Jan 2007 to Feb 2015.
Material and Methods: The relevant history, demographic features, clinical presentations and subtypes of GBS in
211 patients fulfilling the clinical and electrodiagnostic criteria were investigated.
Results: The average age of the patients was 37.36 years (62.7% M, 37.3% F). Clinically 66.8%, 17.8% and 15.4%
presented as ascending paralysis, simultaneous quadriparesis and paraparesis respectively. About 38.1% of the
patients presented with cranial nerves involvement, 87.4% presented with areflexia while 59.5% reported pain.
The GBS subtypes identified were acute inflammatory demyelinating polyneuropathy (21.9%), acute motor
axonal neuropathy (38.9%), acute motor sensory axonal neuropathy (35.6%) and fisher syndrome (3.6%).
Conclusion: The GBS presents in young, as an ascending paralysis, main subtypes of GBS in Pakistan are axonal
and this highlights the importance of local management guidelines and preventive medicine.

Key words: Acute inflammatory demyelinating polyneuropathy, Acute motor axonal neuropathy, Acute motor sensory axonal neuropathy, Fisher syndrome, Guillain-Barré syndrome.



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