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Original Article

PAFMJ. 2018; 68(1): 29-33


EVALUATION OF CHRONIC KIDNEY DISEASE PATIENTS FOR INSULIN RESISTANCE IN TERTIARY CARE HOSPITAL

Sufyan Tahir, Asma Hayat, Saleem Ahmed Khan, Tariq Mahmood Ahmad, Saqibah Rehman, Numan Majeed.

Abstract
Objective: To evaluate the patients of chronic kidney disease for insulin resistance.
Study Design: Cross sectional observational study.
Place and Duration of Study: The study was conducted in the chemical pathology department of Army Medical
College/Military Hospital Rawalpindi, from Nov 2016 to Apr 2017.
Material and Methods: Fifty patients were recruited for this study with deranged renal functions and/or having
any structural renal abnormality for more than 3 months. These patients did not have any history of diabetes and
dialysis. Fifty ages matched healthy individuals were included as controls. Renal function tests, lipid profile,
complete blood count, fasting plasma glucose and serum insulin levels were performed in all subjects. Insulin
resistance was calculated by using homeostatic model for assessment of insulin resistance (HOMA-IR). Results of
this study were analyzed on SPSS version 23.
Results: Fasting insulin levels were much higher in the patient with chronic kidney disease as compared to
controls (p-value=0.001). HOMA-IR in cases was also significantly higher. Statistical comparison of lipid profile
showed significant difference of only triglycerides level.
Conclusion: HOMA-IR is markedly raised in the patients of chronic kidney disease. This indicates a significant
association of chronic kidney disease with insulin resistance.

Key words: Chronic kidney disease, Hypertriglyceridemia, HOMA-IR, Insulin resistance


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