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Original Article

J App Pharm Sci. 2018; 8(7): 100-107

Mild Permanent Chronic Thyroid Hormones Insufficiency Induces Cognitive Dysfunction in the Adult Male and Female Rats

Mohammad Reza Afarinesh, Mahdieh Taheri, Tahereh Haghpanah, Fatemeh Nouri, Iman Znangiabadi, Mohsen Abedini Esfahlani, Khadijeh Esmailpour, Yaser Masoumi-ardakani, Fatemeh Gloshan, Vahaid Sheibani.



Objectives: Hypothyroidism is believed to result in irreversible neurological and cognitive impairments. The aim of this study was to examine cognitive functions of male and female rat offspring exposed to 6-propyl-2-thiouracil (PTU) following levothyroxine-therapy.
Materials and Methods: Wistar rats were used for the experiment. To induce chronic mild neonatal hypothyroidism in rat offspring, PTU (1.5, 3, and 6 ppm) was added to drinking water of the rat offspring from postnatal day 1 to week 12. In the separated group, levothyroxine (50mg/kg. SC) was injected in the Hypo 6 ppm. Morris water maze (MWM) and novel object recognition (NOR) tests were performed at weeks 10 and 12 respectively.
Results: : In both male and female rats, there was an increase (P

Key words: hypothyroidism; Spatial learning; Morris Water Maze; Novel object recognition; Rats

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