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Hemolytic Uremic Syndrome: Single Centre Experience

Can Huzmeli, Hatice Terzi, Ferhan Candan, Meryem Timucin, Ayse Seker, Mehmet Sencan, Mansur Kayatas.

Introduction: Hemolytic uremic syndrome (HUS) is a clinical syndrome characterized by non-immune microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. In this study, we aimed to evaluate patients diagnosed with HUS in our clinic.
Method: Patients who were diagnosed with HUS as clinic and laboratory between August 2012 and October 2017 were included in our nephrology clinic. Biochemistry, haemogram, ANA, anti-Ds DNA, p-ANCA, c-ANCA, anti-GBM antibody, C3, C4 of patients were studied. In some cases, ADAMTS13 was studied and renal biopsy was performed. The demographic features, clinics, and treatments of our cases were reviewed.
Results: A total of 18 patients were enrolled in the study, the average age of the patients was 48.3 (21-82) and 10 of the cases were female and 8 of the cases were male. Among the etiologic causes of HUS in patients; the complement factor B mutation, complement factor H polymorphism, breast cancer, herbal medicine, infections and idiopathic were detected. Primer glomerulonephritis was detected in 6 cases of renal biopsy.
Conclusion: Clinical and laboratory remission was obtained in 13 patients. End-stage renal failure developed in 3 of our patients.

Key words: Acute kidney damage, Hemolytic anemia, thrombocytopenia, eculizumab

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Journal of Molecular Pathophysiology


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