Physalis peruviana L. (Cape gooseberry) is a plant widely cultivated in the Andean mountain in South America and its calyces are the main by-product of the harvest and commercialization of the fruits. Hypoglycemic activity was evaluated to both hydroethanolic extract and its fractions by glucose tolerance test methodology. Since butanolic fraction exhibited hypoglycemic activity as well as the hydroethanolic extract, this fraction was microencapsulated in hypromellose phthalate (HPMCP) by emulsification-evaporation method. Rutin was the major flavonoid in the whole extract and butanolic fraction. By using Plackett-Burman and Box-Behnken statistical experimental designs, were development and optimized HPMCP-microparticles loaded with butanolic fraction. Optimized microparticles has an entrapment efficiency of 71% and yield of 64%, only 8% of release at acidic pH and significant hypoglycemic activity. Development and optimization of microencapsulated butanolic fraction of calyces from P. peruviana is an important contribution to improve the its hypoglycemic activity as a promising therapeutic alternative.
Hypoglycemic activity, microparticles, Physalis peruviana calyces, rutin.
Improving cell transplantation by understanding and manipulating the phagocytic activity of peripheral glia.
Nazareth L, St John J, Ekberg J
Neural regeneration research. 2022; 17(2): 313-314
Significance of mitochondrial activity in neurogenesis and neurodegenerative diseases.
Ozgen S, Krigman J, Zhang R, Sun N
Neural regeneration research. 2022; 17(4): 741-747
In Vitro Assessment of Drug Activity Against Mycobacterium ulcerans.
Komm OD, Almeida DV, Converse PJ, Nuermberger EL
Methods in molecular biology (Clifton, N.J.). 2022; 2387(): 189-194
Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis.
Zhang M, Zhang X, Tian T, Zhang Q, Wen Y, Zhu J, Xiao D, Cui W, Lin Y
Bioactive materials. 2022; 8(): 368-380
Additively manufactured biodegradable porous magnesium implants for elimination of implant-related infections: An and study.
Xie K, Wang N, Guo Y, Zhao S, Tan J, Wang L, Li G, Wu J, Yang Y, Xu W, Chen J, Jiang W, Fu P, Hao Y
Bioactive materials. 2022; 8(): 140-152