Abstract

Background: Understanding the aging process has become one of the global concerns as the world faces the new challenges of an aging population. Central to this phenomenon is cellular senescence, marked by an irreversible growth arrest due to cellular damage. Gut microbiome is a dynamic community of microorganisms influenced by diet, environmental exposures, and aging. Objective: This research highlights the significant impact of gut microbiota composition on overall health, particularly in older adults, where deterioration in microbial diversity can lead to adverse health outcomes. Kombucha, a fermented tea beverage, has emerged as a potential gut microbiota modulator, offering antioxidant properties and digestive support. Specifically, Kombucha derived from Areca catechu shows promise in modulating inflammatory markers and gut microbiota composition. Methods: This review synthesizes current literature on the relationship between aging, frailty, and gut health, with a particular focus on gut microbiota composition and chronic inflammation, referred to as “inflammaging.” We specifically investigate the potential of Kombucha, a fermented tea beverage, to modulate gut microbiota and inflammatory markers. Results: Kombucha, a fermented tea beverage, has emerged as a potential gut microbiota modulator, offering antioxidant properties and digestive support. Specifically, Kombucha derived from Areca catechu shows promise in modulating inflammatory markers and gut microbiota composition. This review synthesizes current literature on the interplay between aging, frailty, and gut health—focusing on the role of gut microbiota and chronic inflammation (“inflammaging”)—to elucidate the therapeutic potential of Kombucha in promoting gut health and mitigating age-related decline, thereby contributing to a deeper understanding of its role in the aging process. Discussion: This research elucidates the therapeutic potential of Kombucha in promoting gut health and mitigating age-related decline, contributing to a deeper understanding of its role in the aging process. The interplay between gut microbiota and chronic inflammation highlights the importance of dietary interventions in managing health in aging populations. Conclusion: Kombucha presents a viable strategy for modulating gut health and addressing the challenges of aging, emphasizing the need for further exploration of its benefits in older adults.

Key words: Kombucha, Microbiota, Inflammatory Marker, Elderly