Home|Journals|Articles by Year Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Article



Therapeutic potential of harmaline, a novel alkaloid, against cervical cancer cells in vitro: Apoptotic induction and DNA interaction study

paromita bhattacharjee, sarita sarkar, tapas ghosh, kakali bhadra.

Abstract
Results converge to suggest that harmaline shows strong binding with CT DNA as revealed by UV absorption, fluorescence spectroscopy, circular dichroism and isothermal calorimetry. The alkaloid showed intercalative mode of binding and induces apoptosis on cancer cell line (HeLa) in comparison to normal cell line (WRL-68). The alkaloid treatment increases ROS generation and shows G2/M phase arrest in HeLa cells.

Key words: beta carb‾ cytotoxicity; ROS; spectroscopy; ITC


Full-text options

Full-text Article


Share this Article


Readers of this article also read the following articles
»A survey on technical approaches in fall detection system
»THE ROLE OF BIOTIC AND ABIOTIC AGENTS IN THE CONTROL OF DAMPING-OFF AND WILT OF BEAN PLANTS
»Blood pressure variations in textile mill middle-aged male workers exposed to noise
»Factors affecting the sleep patterns of hospitalized patients during the early post-operational period
»Lithium ascorbate as a protector of human blood biomolecules under ethanol impact
»Influence of charcoal-based soil amendments on growth and nutrient uptake of rice (Oryza sativa) in Cadmium contaminated soil
»Physiological response of native ecotypes of Cladophora glomerata (L.) Kützing (Chlorophyceae) in relation to salinity
»The effect of chloramphenicol and copper on the cell ultrastructure of Scenedesmus sp.
»Formulation and evaluation of simvastatin buccal film
»Intramuscular arteriovenous malformation in the upper extremity
»Disintegrant properties of banana starch obtained from the unripe fruits of Musa sapientum L



Advertisement
Oxidants and Antioxidants in Medical Science

SUBMIT YOUR ARTICLE NOW




ScopeMed.com
BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.