Acute pulmonary embolism is a common, treatable, but potentially fatal condition which is currently the third most common cause of cardiovascular death. We describe 2 case reports of young active otherwise healthy male, presenting with dry irritating cough and shortness of breath of short duration .A persistent tachycardia, tachypnea, negative Troponin T test, with dilated right atrium (RA), right ventricle (RV) and elevated pulmonary artery (PA) pressure on echocardiography made us suspect pulmonary artery embolism. Computed tomography pulmonary angiography (CTPA) done urgently confirmed diagnosis of pulmonary artery thrombosis. Prompt treatment with antifibrinolytic and anticoagulant relieved them from symptoms and saved them from a mortal condition. Later on Protein S deficiency was established.
Key words: Protein S deficiency, Pulmonary embolism, Shortness of breath, Young male