BACKGROUND & OBJECTIVES: Systemic lupus erythmatosus (SLE) is an autoimmune disease and more than 100 auto antibodies have been detected in SLE. The present study was designed to determine the presence of anti-thyroid antibodies (ATA) in SLE patients.
METHODS: It was a descriptive study and 42-SLE patients positive for anti-nuclear antibodies (ANA) and or anti-ds DNA (ds-DNA) antibodies were selected from Department of Rheumatology, Sheikh Zayed Hospital Lahore. Blood sample was collected and ATA was determined by indirect immunofluorescence technique.
RESULTS: Thirty-nine (39) (92.9%) and 32 (76.2%) patients had ANA and ds-DNA antibodies respectively. On comparison, it was not statistically significant. Twenty- three (23) (54.76%) subjects had ATA and on comparison, it was not statistically significant. All the positive patients for ATA were females.
CONCLUSION: Sensitivity of ANA and ds-DNA positive suspected SLE subjects to have ATA in their serum was 74%. About 55% of SLE patients were positive for ATA.
Systemic lupus erythematosus, Anti-thyroid antibodies, Immunofluorescence
Clinical Performance of Two Automated Immunoassays, EliA CTD Screen and QUANTA Flash CTD Screen Plus, for Antinuclear Antibody Screening.
Yoon S, Moon HW, Kim H, Hur M, Yun YM
Annals of laboratory medicine. 2022; 42(1): 63-70
Cell Free Remodeling of Glycosylation of Antibodies.
Mota LM, Tayi VS, Butler M
Methods in molecular biology (Clifton, N.J.). 2022; 2370(): 117-146
Comparison of the Automated Fluorescent Immunoassay System With Roche Elecsys and Beckman Coulter Access 2 Assays for Anti-MÃ¼llerian Hormone Measurement.
Han A, Suh B, Yi G, Lee YJ, Kim SE
Annals of laboratory medicine. 2022; 42(1): 47-53
Hormone Immunoassay Interference: A 2021 Update.
Ghazal K, Brabant S, Prie D, Piketty ML
Annals of laboratory medicine. 2022; 42(1): 3-23
Role of HSPGs in Systemic Bacterial Infections.
Aquino RS, Hayashida K, Hayashida A, Park PW
Methods in molecular biology (Clifton, N.J.). 2022; 2303(): 605-625