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Original Article

AJVS. 2018; 57(1): 106-114

Clinical Evaluation of Intravenous Propofol Alone or in Combination With Diazepam, Ketamine Hcl and Thiopental Sodium to Induce General Anaesthesia in Dogs

Maha F. Shaaban, Moustafa M. Kassem, Mahmoud H. EL Kammar, Sherif A. Korittum.


This study aimed to evaluate hemato-biochemial and clinico-physiological effects in addition to the anesthetic properties of propofol alone or in combination with diazepam, ketamine Hcl and thiopental sodium. For this purpose, 12 apparently healthy male dogs were randomly divided into four equal groups. A, B, C and D . All dogs were permedicated with (1mg/kg xylazine Hcl (1mg/kg Bwt/IM) then intravenous anesthesia was induced in group A with(5 mg/kg Bwt)propofol or with propofol and ketamine hydrochloride mixture( 2mg/kg Bwt of each drug in group B ,or with propofol and thiopental mixture (2.5 mg/kg propofol and 6,5 mg/kg thiopental) in group c while group D receveid propofol (2mg/kg Bwt) followed 0.2mg/kg Bwt diazepam. Blood samples were collected from the four groups 15 minutes before anesthesia induction, then at (15, 45, 75 and 120) minutes after treatments for the hemato-biochemical evaluation, also clinico-physiological observations were recorded at the same previous times. A slight alterations in some physiological parameters and hemato-biochemical values was observed after anesthesia induction in the four groups, but it still safe to induce general anesthesia in dogs. Moreover , propofol –thiopental mixture showed longest anesthesia duration with complete muscle relaxation and sedation that is suitable for most surgical operations.

Key words: General anesthesia, propofol , diazepam, ketamine, thiopental, anaesthetic combinations, dogs.

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