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Phytomedical Potentials of Chromolaena Odorata Against Arsenic-Induced Testicular Toxicity In Wistar Rats

Olufunke Eunice Ola-Davies, Abimbola Adetokunbo Oloye, Samuel Olumide Ajani.


The testicular, sperm and endocrine protective properties of Chromolaena odorata (CA) in arsenic treated rats were investigated using forty male wistar rats (190-200g) grouped into 4 (A to D) of ten rats each. Oral administrations for 2 weeks of 0.2ml corn oil (A), 2.5mg/kg of sodium arsenite (B), 200mg/kg ethanol leaf extract (ELE) of CA (C), 200mg/kg ELE of CA and 2.5mg/kg sodium arsenite given at 1 hour interval (D) were done. Twenty-four hours after final administrations, semen, blood biochemical and hormonal analysis were carried out after sacrifice of rats. Results revealed that Group C’s mean scrotal circumference, Left and Right testicular weights were highest across groups and significant compared to group B values (p0.05) highest mean value of sperm motility across the groups just as group A was significantly (p

Key words: Chromolaena odorata, reproductive toxicity, arsenic,testicular,Wistar rats

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