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Sequence Characterization and Insilico Anti-biofilm Activity Prediction of β Defensin 103A in Tharparkar Cattle Breed and Taurine Cattle

Ankita Gurao, Ranjit Singh Kataria, Sudhir Kumar Kashyap, Ravinder Singh.


Among the plethora of biological roles, some peptides perform the role of an antimicrobial agent. One of the antimicrobial peptides with cationic charge is β-defensins. Unlike the synthetic antimicrobial agents, the antimicrobial peptides are capable of killing bacteria not only in the planktonic stage but also in a biofilm stage. In bovines, mastitis is an intramammary infection which derives its redundancy for antibiotics due to the biofilm formation and subsequent prophylactic doses of which leads to antimicrobial resistance. Among bovine β-defensins, the β-defensin 103A with high homology to human β-defensin 103 or hBD3 is abundantly expressed on epithelial membranes. Therefore considering the β-defensin 103A as a target, we have bifurcated the present study to address the antibiofilm problem using this cationic peptide in two ways i.e., characterizing the β-defensin 103A mature peptide coding region sequences in cattle breed (Tharparkar; Bos indicus) lesser susceptible to mastitis and using the translated peptide as a template to predict insilico the potent anti-biofilm peptide. In the end of this study, we suggest the predicted peptides from β-defensin 103A peptide as an anti-biofilm peptide with a future prospect as Immune Defense Regulator for mastitis.

Key words: Beta-defensin 103A, Anti-Biofilm Activity, Mastitis, Bos indicus

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