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AAM. 2022; 11(1): 10-21

Effect of Majoon-e-Falasafa and Safoof-e-Aqarqarha in Hypothyroidism - A Randomized Controlled Clinical study

Kaleem Ahmad, Mansoor Ahmad Siddiqui, Mohd Aleemuddin Quamri.


Objective: Hypothyroidism is one of the most common endocrinal disorders worldwide characterize as a clinical syndrome that occurs due to decreased functioning of thyroid hormones lead to varieties of clinical and biochemical signs and symptoms. Autoimmunity, 131I-therapy, and thyroidectomy account for 90% of the causes of thyroid hormone deficiency. The use of levothyroxine is lifelong and controversial in certain conditions. Today, there is a need to seek herbs as an alternative therapy. The present clinical trial was conducted to evaluate the effect of Majoon-e-Falasafa and Safoof-e-Aqarqarha in Hypothyroidism - A Randomized Controlled Clinical Study. Methods: This study was carried out on 40 patients after the screening of 56 subjects. All enrolled patients were randomized by computer-generated random numbers into two groups, 30 in the test group and 10 in the control group, and assessing on subjective & objective parameters. All data analyses were done by using paired proportion tests and student t-test before and after to assess the effect of interventions. Result: The demographic data of both groups were similar at baseline. The all-subjective & objective parameters significantly improved (P0.05). The TSH was significantly improved by 26.7% (P=0.013) in the test group and 50% (P=0.06) in the control group at baseline and after treatment. No significant difference (intergroup P>0.05) were observed in all subjective and objective parameters between groups at baseline and after treatment except free T4. Conclusion: The test intervention has an effect on subjective and objective parameters but the control group was superior to the test group. [Trial registration: CTRI/2018/02/011768].

Key words: Hypothyroidism, Majoon-e-Falasafa, Aqarqraha (Anacyclus pyrethrum), levothyroxine, Herbal, Autoimmunity

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