Abstract

Background : The relationship between uric acid and microalbuminuria in healthy adults without other cardiovascular risk factors may help to clarify the role of uric acid in cardiovascular disease.
Objectives: To study and compare the association of serum uric acid levels with microalbuminuria in normotensive and prehypertensive subjects without a history of cardiovascular disease or renal dysfunction.
Material and Methods :350 subjects were included in study. All the routine investigations along with serum uric acid and urinary albumin were conducted . Microalbuminuria was detected by immunoprecipitation in a random urine sample. Serum uric acid level was estimated by Spectrophotometry.
Results:The overall prevalence of prehypertension was 38.06% (Males,39.10% and females, 35.56%). The total prevalence of microalbuminuria was 11.61% ( 9.9% of normotensives and 14.4% of prehypertensives ).Hyperuricemia was seen in 10.32% of the total study population.Among normotensives, 9% of males and 8.6% of females and in prehypertensive subjects, 14% of males & 9.4% of females had hyperuricemia. Among the prehypertensives, those with microalbuminuria had a significantly higher (p

Key words: Microalbuminuria, Uric acid ,prehypertension, India.