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Original Research

RMJ. 2018; 43(3): 488-490

Efficacy of Chlorzoxazone versus Orphenadrine in the management of pain associated with cervical spondylosis

Laith Thamer Al-Ameri, Sinan Bahjat Issa, Ahmad Abd Marzook, Ekhlas Khalid Hameed, Noor Hamdi Jasem.


Objective: To assess and compare the efficacy of two muscle relaxants, chlorzoxazone and orphenadrine, in the management of pain associated with cervical spondylosis.
Methodology: A prospective randomized clinical trial was carried out on 60 adults diagnosed with cervical spondylosis. Patients were randomly divided into two groups with 30 patients in each. The first group received chlorzoxazone 250 mg twice daily, while the second group received orphenadrine 35 mg twice daily for two weeks. Both groups received similar additional management. Pain severity was assessed by Visual Analogue Scale (VAS) at day zero, 7 and 14. Data were analyzed using T-test, repeated measure ANOVA and pairwise comparisons.
Results: Pain score was significantly lower for both chlorzoxazone and orphenadrine group with p-value of 0.001 and 0.002, respectively. The chlorzoxazone group showed significantly lower pain score than the orphenadrine group at day 7 and 14 with p-value of 0.034 and 0.014, respectively. All patients showed reduction in mean of pain score (p=0.001).
Conclusion: chlorzoxazone was more effective than orphenadrine in pain management for patients with cervical spondylosis at day 14. Both showed significant pain reduction.

Key words: Cervical spondylosis, muscle relaxants, chlorzoxazone, orphenadrine

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