Background: Thyroid hormones regulate a wide array of metabolic parameters and exert effects virtually on every organ system. Subclinical hypothyroidism is more common than overt hypothyroidism, and an apparently asymptomatic condition defined by slightly increased serum thyrotropin (TSH) concentrations, but normal serum-free T3 and free T4 hormone levels.
Aims and Objectives: The aims of this study were to find a correlation between subclinical hypothyroidism (SCH) and the parameters of lipid profile.
Materials and Methods: Study was carried out in 25 newly diagnosed subclinical hypothyroid subjects and compared with age- and sex-matched controls. Statistical analysis was done using regression analysis with alcula software.
Results: SCH was more common in females and incidence increased as age advanced. Mean cholesterol, total triglycerides (TG), low-density lipoproteins (LDL), and very LDL (VLDL) increased proportionately with TSH level and high-density lipoproteins (HDL) decreased as TSH increased.
Conclusion: SCH appears to be associated with dyslipidemia, that is, increased total cholesterol, TG, LDL, and decreased HDL.
Key words: Subclinical Hypothyroidism; Lipid Profile; Total Cholesterol; Triglycerides; Low-density Lipoproteins; High-density Lipoproteins; Very Low-density Lipoproteins; Dyslipidemia
|
