Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Original Research

Effect of Hordeum vulgare, Moringa oleifera, and Vitex negundo extracts on the hippocampus and memory of Mus musculus

Justine Ann D Cudiamat, Diana Rose Gatmaytan, Nicolo Kristoff Gonzalez, Michael B Ples, Rodel Jonathan Santos Vitor II.

Background: Herbal medicines such as Hordeum vulgare, Moringa oleifera, and Vitex negundo are widely recognized around the world as dietary supplements, remedy for ailments, and bodily sustenance. Moreover, studies have shown that intake these herbal medicines can have an effect in the memory retention in mice; however, no further studies have been conducted in comparing between barley, moringa, and lagundi and their optimal dosages on treatments for the effect of memory in mice.

Aims and Objectives: The aim of this study is to comparatively assess the effects barley, moringa, and lagundi extracts on the histology of the hippocampus and its effect on memory using the Morris Water Maze test.

Materials and Methods: The extracts were orally administered to the mice with three specific dosages (250 mg/kg, 500 mg/kg, and 750 mg/kg) of each herbal supplements, barley, moringa, and lagundi. The mice were subjected to a 2-day water maze test, and mice were sacrificed thereafter. Neurological effects such as hippocampal reduction and degeneration were analyzed histologically.

Results: Results showed that there are no differences between the different treatments at all dosages with the control group; therefore, memory improvement or impairment was not exhibited during the maze test. In the histological analysis, however, it showed that barley did not show any effect on the histology of hippocampal neurons with the cells within the normal limit and did not undergo cell degeneration. Moringa and lagundi, on the other hand, resulted to neurotropic effects of impaired hippocampal neurons with lagundi causing more damage than moringa.

Conclusion: There are no effects on memory between the three treatments administered to the mice. However, neuronal damage on the other may result from moringa and lagundi administration.

Key words: Barley; Hippocampus; Lagundi; Memory; Moringa

Similar Articles

Research advances on how metformin improves memory impairment in "chemobrain".
Alhowail A, Chigurupati S
Neural regeneration research. 2022; 17(1): 15-19

Contribution of adult-born neurons to memory consolidation during rapid eye movement sleep.
Ohba A, Sakaguchi M
Neural regeneration research. 2022; 17(2): 307-308

Isolation and Culture of Adult Hippocampal Precursor Cells as Free-Floating Neurospheres.
Rust R, Walker TL
Methods in molecular biology (Clifton, N.J.). 2022; 2389(): 33-44

Diffusion tensor imaging of the hippocampus reflects the severity of hippocampal injury induced by global cerebral ischemia/reperfusion injury.
Wang WZ, Liu X, Yang ZY, Wang YZ, Lu HT
Neural regeneration research. 2022; 17(4): 838-844

Safety and efficacy of dietary supplement (gintonin-enriched fraction from ginseng) in subjective memory impairment: A randomized placebo-controlled trial.
Lee WJ, Shin YW, Chang H, Shin HR, Kim WW, Jung SW, Kim M, Nah SY
Integrative medicine research. 2022; 11(1): 100773

Full-text options

Latest Statistics about COVID-19
• pubstat.org

Add your Article(s) to Indexes
• citeindex.org

Covid-19 Trends and Statistics
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.

ScopeMed Web Sites