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Research Article

JCR. 2020; 7(18): 4180-4185


ANTI-OXIDANT AND HYPOGLYCEAMIC POTENTIAL OF PHALLUS IMPUDICUS (L. EX PERS) (STINK HORN) MUSHROOM IN ALLOXAN INDUCED DIABETIC RATS

Abdur Rahim Khan, Dr. Muhammad Fiaz, Dr. Rahmat Ali Khan, Dr. Zainul Wahab, Jan Baz Khan, Inam Khan, Dr. Muhammad Wasim Jan Khan.

Abstract
Mushrooms are used traditionally as nutrition, medicines and as a tonic for ages. This study was aimed to
evaluate the free radical scavenging potential of Phallus impudicus aqueous extract (PIAE) using (DPPH),
(ABTS+) and Hydrogen peroxide (H2O2), While for in-vivo hypoglycemic characterization of (PIAE), Body
weight, Blood glucose level, Serum lipids profile ( TC,HDL, LDL, TG) and urine profile (Glucose, Cretanine,
Total protein ) were evaluated. PIAE showed significant inhibitory effects in DPPH, ABTS+ and H2O2 assays by
providing significant IC50 values at a concentration of 7.30±0.03mg/ml in the DPPH, 9.46±0.02mg/ml in ABTS
and 15.43±1.15 in H2O2 which was significant as compared to control (5.33±0.43 mg/ml), While in-vivo study
of PIAE was conducted by administering single oral dose of 200-400 mg/kg body weight on daily basis to six
groups of albino rats for twenty one (21) days. The effects of PIAE on body weight, blood glucose, lipids profile
and urine profile were studied. Treatment with PIAE showed a significant maximum increase in the body
weight (5.30±0.05% ) and decrease in the blood glucose level (6.60±0.04% ) as compared with diabetic
control. After the treatment of 21 days urine (by pressing slightly abdominal area on aluminum foil) and blood
was collected by means of cardiac puncture. The serum lipid profile of diabetic rats treated with PIAE
significantly recovered to normal control. The urine profile was also considerably recovered. So from the
present study we conclude that P. impudicus may be used as an anti-oxidant and as a hypoglycemic agent.

Key words: Medicinal mushrooms, Phallus impudicus, anti-oxidant, Diabetic rats, hypoglycemic effects



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