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Case Report

EJMCR. 2018; 2(2): 59-62

Comparison of 99mTc(V)-DMSA with 99mTc-EDDA/HYNIC-Tyr3-Octreotide Scintigraphy in the detection of Medullary Thyroid Tumor Foci in a patient with elevated level of Calcitonin after surgery: a case report

Hameed ullah, Aakif Ullah Khan, Muhammad Rauf Khattak, Shakil Ahmad, Shaheen Iqbal.

Background: Technetium-99m Pentavalent Dimercaptosuccinic acid (99mTc(V)-DMSA) scintigraphy exhibit a crucial role in the preoperative assessment of residual or recurrence Medullary Thyroid Carcinoma (MTC).
Case Presentation: 99mTc(V)-DMSA scintigraphy was performed in a patient with histopathologically proven MTC expressing high level of calcitonin using a locally formulated kit. Marked uptake of the radiotracer was observed by the locally metastatic foci. The same patient was then subjected to somatostatin receptor scintigraphy (OctreoScan) and the results were found comparable. Both the scanning was completed within 24hrs with good quality images.
Conclusion: In-house preparation from renal DMSA kit, better resolution, good stability and easy procedure with minimum cost make 99mTc(V)-DMSA, a good imaging agent for visualization of medullary thyroid carcinoma in the centers where 99mTc-EDDA/HYNIC-Tyr3-Octreotide is not available.

Key words: Calcitonin, MTC, Octreotide, Radiochemical purity, 99mTc (V)-DMSA

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