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Antibacterial and Antibiofilm Activities of Sesbania grandiflora Against food-borne pathogen Vibrio cholerae

John Paul Matthew Domingo Guzman, Athena Dana Cortes, Kimberly Dimaano Neri, Trisha Pamela Lim De las Alas, Christine Eden Cortez.

Abstract
The progressing threat of antimicrobial resistance to global public health remains a problem yet to be solved. Hence, new natural products and novel strategies in combating bacteria are continuously being discovered. In this study, Sesbania grandiflora was tested for its antibacterial and antibiofilm activities against the pathogenic Vibrio cholerae. S. grandiflora was able to yield growth inhibition at 7.81 mg/mL and was bactericidal at 15.63 mg/mL. However, it was only able to start to actively inhibit growth at 125 mg/mL. S. grandiflora ethanolic extract was also able to significantly inhibit biofilm formation at concentration as low as 0.98 mg/mL. Hence, the results show the concentration-dependent antibiofilm activity of S. grandiflora that it was able to inhibit biofilm formation without completely eradicating the microorganism at lower concentrations. These activities were due to their phytochemical composition which exhibit antibacterial and antibiofilm activities. Isolation and characterization of their bioactive compounds may enhance the efficacy of their activities.

Key words: Sesbania grandiflora, Antibacterial, Antibiofilm, Katuray, Vibrio cholerae, biofilm



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