Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Original Article

Prog Med Sci. 2017; 1(1): 1-8


Comparative Anti-hyperglycemic Effects of the Aqueous Extracts of Combretum molle Twigs in Rats

David Miaffo, Amadou Daw, Sylvie La Wansi, Sylviane Laure Kamani Poualeu, Gilbert Todou, Albert Kamanyi.

Abstract
Aim: To evaluate the antidiabetic properties of the aqueous extracts of C. molle twigs in rats. Methods: For the anti-hyperglycemic tests, the extracts at doses of 125, 250 and 500 mg/kg were administered orally to the normal rats and their glycemia was evaluated each 30 minutes during 4 hours. Type 1 diabetes was induced by the intra-peritoneal injection of alloxane (150 mg/kg) in rats. Type 2 diabetes was induced by the sub-cutaneous injection of the dexamethasone (1 mg/kg). Afterwards, animals were treated at doses 250 and 500 mg/kg of the decoction for 14 days (type 1 diabetes) and 8 days (type 2 diabetes). Body weight, glycemia, lipid parameters and atherogenic index were evaluated. Results: The decoction (250 mg/kg) produced a significant (p < 0.05) decrease in the postprandial glycemia at 90 minutes. However, at 120 minutes, a significant regulation of the blood glucose was observed at the dose of 500 mg/kg of the decoction (p < 0.01), maceration (p < 0.05) and infusion (p < 0.05). In addition, the doses 250 and 500 mg/kg of the decoction of C. molle prevented a significant reduction in body weight, hyperglycemia and dyslipidemia, and a significant increase in atherogenic index, which were observed in the type 1 and 2 diabetic subjects. Conclusion: The decoction was showed the greatest hypoglycemic and anti-hyperglycemic activities, thereby confirming his ethnopharmacological use of this extract in the management of diabetes mellitus.

Key words: Combretum molle, diabetes mellitus, lipid profile, aqueous extracts, Wistar rats


Full-text options

Full-text Article




Advertisement
American Journal of Diagnostic Imaging

SUBMIT YOUR ARTICLE NOW




ScopeMed.com
BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.