Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Article

Prog Med Sci. 2017; 1(1): 1-8


Comparative Anti-hyperglycemic Effects of the Aqueous Extracts of Combretum molle Twigs in Rats

David Miaffo, Amadou Daw, Sylvie La Wansi, Sylviane Laure Kamani Poualeu, Gilbert Todou, Albert Kamanyi.

Abstract
Aim: To evaluate the antidiabetic properties of the aqueous extracts of C. molle twigs in rats. Methods: For the anti-hyperglycemic tests, the extracts at doses of 125, 250 and 500 mg/kg were administered orally to the normal rats and their glycemia was evaluated each 30 minutes during 4 hours. Type 1 diabetes was induced by the intra-peritoneal injection of alloxane (150 mg/kg) in rats. Type 2 diabetes was induced by the sub-cutaneous injection of the dexamethasone (1 mg/kg). Afterwards, animals were treated at doses 250 and 500 mg/kg of the decoction for 14 days (type 1 diabetes) and 8 days (type 2 diabetes). Body weight, glycemia, lipid parameters and atherogenic index were evaluated. Results: The decoction (250 mg/kg) produced a significant (p < 0.05) decrease in the postprandial glycemia at 90 minutes. However, at 120 minutes, a significant regulation of the blood glucose was observed at the dose of 500 mg/kg of the decoction (p < 0.01), maceration (p < 0.05) and infusion (p < 0.05). In addition, the doses 250 and 500 mg/kg of the decoction of C. molle prevented a significant reduction in body weight, hyperglycemia and dyslipidemia, and a significant increase in atherogenic index, which were observed in the type 1 and 2 diabetic subjects. Conclusion: The decoction was showed the greatest hypoglycemic and anti-hyperglycemic activities, thereby confirming his ethnopharmacological use of this extract in the management of diabetes mellitus.

Key words: Combretum molle, diabetes mellitus, lipid profile, aqueous extracts, Wistar rats



Share this Article


Advertisement
American Journal of Research in Medical Sciences

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.