Acute pancreatitis is a relatively common disease with an estimated annual mortality rate of about 7%. Drug-use is a major etiological factor in the pathogenesis and pathophysiology of the condition. The aim of this study was to evaluate the effects of tomato extract on carbimazole-induced biochemical alterations in the pancreas of albino rats. phytochemical analysis of the tomato extract was done. A total of 24 male albino wistar rats weighing (225±25g) were randomly divided into 4 groups (A−D) with six rats per group. Group A served as the normal control group and received no treatment. Group B received only carbimazole (60mg/kg, oral) and served as the negative control group. Group C received vitamin C (200mg/kg, oral) and served as the positive control and Group D which served as test group received tomato extract (30mg/kg, oral) in the presence of carbimazole challenge for 4 weeks. Carbimazole administration to rats resulted in pancreatic damage with glucose, amylase, triglycerides and total protein levels: 126.33±6.64 mg/dl; 484.00±18.33 IU/L; 0.75±0.09 mmol/l and 4.83±0.12 g/dl respectively. The daily administration of tomato extract resulted in the mitigation of the carbimazole-induced pancreatic damage with glucose, amylase, triglyceride and total protein levels: 106.33±296 mg/dl (p˂0.01); 333.33±44.10 IU/L (p˂0.01); 2.80±0.31 mmol/l (p>0.05) and 6.33±0.44 g/dl (p>0.05) respectively. Tomato (Lycopersicon esculentum) possesses pancreas-protective property against carbimazole-induced pancreatic damage.
Key words: Acute pancreatitis, Albino rats, Carbimazole, Pancreatic protection, Tomato
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