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Original Article

J App Pharm Sci. 2018; 8(3): 120-125

Chemical study and evaluation of antioxidant activity and α-glucosidase inhibition of Myrciaria strigipes O. Berg (Myrtaceae)

Rafael Destefani Faitanin, João Victor Dutra Gomes, Luís Fernando T. Menezes, Álvaro Cunha Neto, Rita de Cásssia Ribeiro Gonçalves, Rodrigo Rezende Kitagawa, Dâmaris Silveira, Claudia Masrouah Jamal.


Myrciaria strigipes O. Berg (Myrtaceae) is a Brazilian native species, endemic of Bahia and Espírito Santo, and known popularly as "cambucá da praia". The aim of this study was to evaluate the chemical profile of ethanol extract of leaves from M. strigipes (EEF), and the two in vitro activities: antioxidant and inhibition of α-glucosidase. The column chromatography separation gave friedelin (1), glutinol (2), β-sitosterol (3), 28-hydroxyfriedelin (4), and ursolic acid (5). The chromatographic profile of EEF by HPLC (354 nm) allowed the identification of three phenolic compounds: ellagic acid (6), hyperoside (7), and isoquercitrin (8). The extract EEF showed antioxidant activity in both models DPPH and ABTS, with EC50 of 61.79 ± 2.97 and 23.72 ± 0.48 µg/ml, respectively. Trolox, used as a standard, showed EC50 of 4.60 ± 0.82 and 1.08 ± 0.05 µg/ml, respectively. The obtained result of the inhibition assay on the enzyme activity of α-glucosidase revealed that EEF had EC50 value of 40.66 ± 0.81 μg/ml, close to the positive standard deoxynojirimycin (EC50 = 37.30 ± 4.41 μg/ml). Therefore, this study contributed to the knowledge of the chemical and biological properties of M. strigipes and will subsidize future studies of this species.

Key words: Myrciaria strigipes, HPLC, Phenolic compounds, Triterpenes, Antioxidant activity, α-glucosidase.

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