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Original Article



Stability Study of Ipomoea reptans Extract Self-Nanoemulsifying Drug Delivery System (SNEDDS) as Anti-Diabetic Therapy

Pinus Jumaryatno, Lutfi Chabib, Farida Hayati, Rizki Awaluddin.




Abstract

Diabetes mellitus (DM) is one of metabolic syndromes that is characterized by the excessive accumulation of blood glucose, also called as hyperglycemia, and carbohydrate, fat, and protein metabolism disorder. The antioxidant compounds on Ipomoea reptans possesses the pharmacological activity on DM with low absorption in systemic circulation. The absorption and penetration properties of the extract can be improved by making it into the SNEDDS (Self-Nanoemulsifying Drug Delivery) dosage form. Stability is one of the factors that affect the safety, quality and efficacy of the SNEDDS dosage form. This study aimed to evaluate the stability of Ipomoea reptans extract (IpE) SNEDDS. The IpE SNEDDS was made using myritol as the oil phase, tween 20 as surfactants, and polyethylene glycol (PEG) 400 as the cosurfactant. The stability study was conducted with several physical stability tests, which were centrifugation test, heating-cooling cycle test, and freeze-thaw cylcle test. The result indicated that the particle size of the IpE SNEDDS was ≤ 200nm and indicated good physical stability. It can be concluded that the IpE SNEDDS possesses good stability profile.

Key words: Ipomoea reptans, SNEDDS, Stability, Myritol, Diabetes Mellitus






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