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Original Article

Pak J Nucl Med. 2012; 2(1): 27-32

The importance of CA125 as a predictive tool in ovarian carcinoma

Affia Tasneem, Ismat Fatima, Munawar Ali Munawar, Adeela Ali, Nasir Mehmood, Muhammad Khaqan Amin.

Aims: The present study deals with the importance of CA125 as an effective tumor marker in ovarian carcinoma and the clinical presentation observed in patients with high CA125 levels. Methods: This Serological tests for tumour marker CA125 were performed in 585 patients with either ovarian carcinoma or some other turnouts such as kidney, uterine, cervical and testicular tumours referred to the centre for nuclear medicine Lahore for hormonal estimation. Further more, some other clinical presentations were also observed amongst the patients. Results: The serum CA125 levels were elevated in 92% subjects with ovarian carcinoma and 8% in non ovarian tumours. Some elevated CA125 levels were observed in the patients with abdominal pain, abdominal extension, uterine fibroid, ovarian cyst, back ache and pelvic mass. Conclusion: CA125 seems to be a reliable marker as its levels were found to be elevated in 92% ovarian tumours.

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