The radionuclide bone scan is a sensitive modality for the detection of skeletal metastases. On occasion, there is incidental detection of soft-tissue lesions, both benign and malignant. We report a case of breast carcinoma with liver metastases where the bone scan showed increased uptake of 99mTc-MDP in the liver. Abdominal ultrasound performed soon after the bone scan revealed metastases in both lobes of liver from breast carcinoma. The intense non-homogenous liver uptake on bone scan using 99mTc-MDP during evaluation of skeletal metastases indicated the presence of liver metastases.
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